From Chapter 3:
Although tobacco was in such general use it yet had plenty of enemies. It was extravagantly abused and extravagantly praised. Robert Burton, of "Anatomy of Melancholy" fame, like many other writers of his time, was prepared to admit the medicinal value of the herb, though he detested the general habit of smoking. Tobacco was supposed in those days to be "good for" a surprising variety of ailments and diseases; but to explore that little section of popular medicine would be foreign to my purpose. Burton believed in tobacco as medicine; but with regard to habitual smoking he was a worthy follower of King James, the strength of whose language he sought to emulate and exceed when he denounced the common taking of tobacco "by most men, which take it as tinkers do ale"—as "a plague, a mischief, a violent purger of goods, lands, health, hellish, devilish, and damned tobacco, the ruin and overthrow of body and soul." No anti-tobacconist could wish for a more whole-hearted denunciation than that.

From Chapter Chapter 8:
Cowper then goes on to attack tobacco in lines which show how unpopular smoking at that date was with ladies, and which have since often been quoted by anti-tobacconists with grateful appreciation:

Pernicious weed! whose scent the fair annoys,
Unfriendly to society's chief joys,
Thy worst effect is banishing for hours
The sex whose presence civilizes ours;
Thou art indeed the drug a gardener wants,
To poison vermin that infest his plants,
But are we so to wit and beauty blind,
As to despise the glory of our kind,
And show the softest minds and fairest forms
As little mercy as the grubs and worms?

Notwithstanding this "satiric wipe," it is not likely that Cowper would have had much sympathy with John Wesley, who, in his detestation of what had been his father's solace at Epworth, forbade his preachers either to smoke or to take snuff.